UPDATE: The Karoonda Highway has been reopened after a serious crash at Wynarka this morning.
At 8.20am Friday 7 July emergency services were called to the Karoonda Highway between Wynarka and Chapman Bore after reports of a two car crash.
The driver of one of the cars, a woman, was airlifted to the Flinders Medical Centre with critical injuries.
The driver of the other vehicle, 63-year-old Mallee man, was also taken to FMC with non-life threatening injuries.
Major Crash officers are investigating the crash.
The Karoonda Highway was closed for several hours but reopened just after 3.00pm.
Anyone who has information or dashcam footage regarding the crash is encouraged to contact Crimestoppers.