Walker Flat residents will be without essential shops come the end of June with the General Store shutting shop.
The post office, petrol station and liquor store all closing when owners Simon and Karen Caddy retire.
The pair have been running the General Store for 8.5 years and have had no luck selling it in the 4.5 years that it has been on the market.
Karen Caddy said it is a surprise no one has snapped it up as it is so essential to the community and is always busy.
"Its such a fabulous little business, there's never any down-time. People are under the impression it goes quiet here in winter but it doesn't - it stays busy all year and just gets busier in summer," Mrs Caddy said.
Originally from Lobethal in the Adelaide Hills, Karen and Simon Caddy plan to move to Mannum to spend more time with their two young grandchildren and the friends they have made during their time in the region.
"Great locals, they're wonderful people here and it's just a great place," Mrs Caddy said.
CE Property Group have both the business and a connecting three-bedroom residence listed for sale to the value of $449,000.
If no one buys the property by the end of June, the riverside town will be without essential services aside from the Walker Flat Corner Store, with the nearest shops 32km away in Mannum.
Walker Flat resident, Joyce Oakes, said the store closure is a blow to the community.
"A huge loss for the locals," Joyce Oakes wrote to us on Facebook.
"Simon and Karen are lovely people. It's a shame they are closing."
Story by Jennie Lenman
Photo of the Walker Flat General Store for sale, courtesy of CE Property Group